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ESZOPICLONE side effects
Rebound insomnia, defined as a dose-dependent temporary worsening in sleep parameters (latency, sleep efficiency, eszopiclone and number of awakenings) compared with baseline following discontinuation of treatment, is observed with short- and intermediate-acting hypnotics .
Rebound insomnia following discontinuation of LUNESTA relative to placebo and baseline was examined objectively in a 6-week adult study on the first eszopiclone 2 nights of discontinuation (nights 45 and 46) following 44 nights of active treatment with 2 mg or 3 mg .
In the LUNESTA 2 mg group, compared with baseline, there was a significant increase in WASO and a decrease in sleep efficiency, both occurring only on the first eszopiclone night after discontinuation of treatment .
No changes from baseline were noted in the LUNESTA 3 mg group on the first night after discontinuation, and there was a significant improvement in LPS and sleep efficiency compared eszopiclone with baseline following the second night of discontinuation .
Comparisons of changes from eszopiclone baseline between LUNESTA and placebo were also performed .
On the first night after discontinuation of lunesta coupon 2017 generic for lunesta in canada why is generic lunesta so expensive lunesta LUNESTA 2 mg, LPS and WASO were significantly increased and sleep efficiency was reduced; there were no significant differences on the second night .
On the first night following discontinuation of LUNESTA 3 mg, eszopiclone sleep efficiency was significantly reduced .
No other differences eszopiclone from placebo were noted in any other sleep parameter on either the first or second night following discontinuation .
For both doses, the discontinuation-emergent effect lunesta birth defects lunesta lethal dose lunesta generic goodrx lunesta generic canada side effects was mild, had the characteristics of the return of the symptoms of chronic insomnia, and appeared to resolve by the second night after LUNESTA discontinuation .
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